Orphengesic® Forte is a multimodal agent. It is an opioid-free pain reliever that combines 3 medications into one pill to help relieve mild to moderate acute musculoskeletal pain.
Each Orphengesic® Forte tablet contains the following:
Orphenadrine Citrate 50 mg - Orphenadrine is a muscle relaxant, which helps to reduce muscle tension and pain due to strains, overuse, and other injuries.
Aspirin 770 mg - Aspirin is a nonsteroidal anti-inflammatory drug (NSAID). Aspirin is effective in alleviating pain, swelling, and fevers.
Caffeine 60 mg - Caffeine is a stimulant. It is often combined with other pain medications, such as aspirin, to increase pain relief.
Orphengesic® Forte is a multimodal agent for treatment of mild to moderate acute musculoskeletal pain.
Aspirin should be used with extreme caution in the presence of peptic ulcers and coagulation abnormalities. Rare GI hemorrhage due to the aspirin content may be associated with the administration of Orphengesic® Forte.
According to a Cochrane meta-analysis of more than 7,000 patients, caffeine was found to have a synergistic effect on pain relief when added as an analgesic adjuvant.
Side effects of Orphengesic® Forte Tablets are those seen with aspirin and caffeine or those usually associated with mild anti-cholinergic agents. These may include tachycardia, palpitation, urinary hesitancy or retention, dry mouth, blurred vision, dilation of the pupil, increased intraocular tension, weakness, nausea, vomiting, headache, dizziness, constipation, drowsiness, and rarely, urticaria and other dermatosis. Infrequently, an elderly patient may experience some degree of confusion. Mild central excitation and occasional hallucinations may be observed. These mild side effects can usually be eliminated by reduction in dosage. One case of aplastic anemia associated with the use of orphenadrine citrate, aspirin and caffeine has been reported. No causal relationship has been established. Rare G.I. hemorrhage due to aspirin content may be associated with the administration of Orphengesic® Forte Tablets. Some patients may experience transient episodes of light-headedness, dizziness or syncope.
Orphengesic® Forte (Orphenadrine Citrate, Aspirin and Caffeine 50 mg, 770 mg, 60 mg) Tablets are indicated in:
1. Symptomatic relief of mild to moderate pain of acute musculoskeletal disorders.
2. The orphenadrine component is indicated as an adjunct to rest, physical therapy, and other measures for the relief of discomfort associated with acute painful musculoskeletal conditions.
The mode of action of orphenadrine has not been clearly identified, but may be related to its analgesic properties. Orphengesic® Forte Tablets do not directly relax tense muscles in man.
Orphengesic® Forte is contraindicated in patients with glaucoma, pyloric or duodenal obstruction, achalasia, prostatic hypertrophy, obstructions at the bladder neck, myasthenia gravis, hypersensitivity to the drug, and known sensitivities to aspirin or caffeine.
The side effects of Orphengesic® Forte are those seen with aspirin and caffeine or those usually associated with mild anti-cholinergic agents. These may include tachycardia, palpitation, urinary hesitancy or retention, dry mouth, blurred vision, dilation of the pupil, increased intraocular tension, weakness, nausea, vomiting, headache, dizziness, constipation, and drowsiness, and rarely, urticaria and other dermatosis.
For more details, please read the Full Prescribing Information for Orphengesic® Forte.
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch, or call 1-800-FDA-1088.